This guide to mitigating risk from climate change across the US highway system contains strategies to deal with the necessary changes infrastructure will need to combat climate change. Dealing with climate change through 2050 and sea level rise through 2100, the guide gives recommendations for all types of assets, including bridges, culverts, pavement, slopes, stormwater infrastructure, and walls. There is also a software tool that provides information based on region, tables with the same information as the software tool, and two spreadsheets of cost-benefit analyses of various adoption strategies.